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. 2018 Apr 11;19:129. doi: 10.1186/s12859-018-2123-4

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A generalized illustration of two alternative approaches involving in drug repositioning; (a), (b) and (c) represent the known interactions, New Target Recognition and New Indication Recognition, respectively. (The notations 1*-1* and m-n indicate one-or-many and many-to-many relationships, respectively)