Table 6.

The inferred repositioning candidates with higher confidence

Drug name	Cluster ID	Old ATC name	New ATC name	Confidence	Algorithm
Amlodipine	403	C08	C09	0.85	MCL
Chlorthalidone	2		C03	0.83	CL1
Amantadine	51	N04	N05	0.80	CL1
Thioridazine	51		N05	0.80	CL1
Hydroxyzine	30	N05	C09	0.75	MCODE
Cyproheptadine	46	R06	N06	0.70	CL1
Amlodipine	11	C08	C09	0.70	CL1
Carvedilol	11	C07	C09	0.70	CL1
Cetirizine	11	R06	C09	0.70	CL1
Acitretin	414	D05	D10	0.67	MCL
Brinzolamide	48	S01	L02	0.67	MCODE
Orphenadrine	392		R06	0.64	MCL
Clonidine	56	C02, N02, S01	N05	0.62	CL1
Thioridazine	56		N05	0.62	CL1
Dofetilide	399	C01	L02	0.60	MCL
Cyproheptadine	35	R06	N06	0.59	CL1
Guanfacine	35	C02	N06	0.59	CL1
Dipivefrin	44	S01	N05	0.57	CL1
Indomethacin	7		M01	0.57	MCODE
Nicardipine	57	C08	N06	0.57	CL1
Cyproheptadine	4	R06	N06	0.54	CL1
Methadone	4	N07	N06	0.54	CL1
Arsenic Trioxide	4	L01	P01	0.50	MCODE
Atropine	48	A03, S01	N04	0.50	CL1
Atropine	393	A03, S01	N04	0.50	MCL
Dacarbazine	79	L01	A10	0.50	GSOM
Hexachlorophene	350	D08	D05	0.50	MCL
Isocarboxazid	50	N06	N05	0.50	MCODE
Levetiracetam	346	N03	L01	0.50	MCL
Lithium	6	N05	N06	0.50	GSOM
Mercaptopurine	4	L01	P01	0.50	MCODE
Metformin	79	A10	L01	0.50	GSOM
Moexipril	26	C09	C07	0.50	CL1
Mycophenolic Acid	342	L04	N03	0.50	MCL
Phenytoin	66	N03	C01	0.50	GSOM
Tazarotene	350	D05	D08	0.50	MCL
Tolterodine	59	G04	C01	0.50	GSOM
Topotecan	346	L01	N03	0.50	MCL
Zonisamide	342	N03	L04	0.50	MCL

Note: ATC code names are given in Additional file 5