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Increased AMPK activity by Wnt3a ligand requires canonical FzR-LRP5/6 and GSK-3β inhibition and does not affect the turnover of phosphatase PP2Ac. a After 30 min, Wnt3a ligand induces AMPK activation, which was abolished by Dkk1 and TCS183 pretreatment. b Measurement of PP2A catalytic subunit levels indicates no changes during time-course treatment. The data are expressed as the mean ± S.E.M. of three independent experiments, **p < 0.001, n.s., non-significant
