Table 1.

Literature review of cyclohexanone metabolite associated diseases

Authors	Disease	Title of the paper	Journal name
Westhoff et al., 2010 [35]	Lung cancer	Differentiation of chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control group by breath analysis using ion mobility spectrometry	International Journal for Ion Mobility Spectrometry
Wei et al., 2012 [36]	Prostate cancer	Effects of cyclohexanone analogues of curcumin on growth, apoptosis and NF-κB activity in PC-3 human prostate cancer cells	Oncology letters
Leung et al. 2012 [37]	Breast cancer	Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells	Investigational new drugs
Wang et al., 2014 [26]	Breast cancer	Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy, and Mammary Gland Fibroma	Scientific Report (Nature)
Mochalski et al., 2014 [38]	Renal disease	Blood and breath profiles of volatile organic compounds in patients with end-stage renal disease	BMC Nephrology
Liu et al., 2014 [39]	Lung cancer	Investigation of volatile organic metabolites in lung cancer pleural effusions by solid-phase microextraction and gas chromatography/mass spectrometry	Journal of Chromatography
Silva et al., 2017 [40]	Breast cancer	Volatile metabolomic signature of human breast cancer cell lines	Scientific Report (Nature)