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. 2018 Apr 11;37:81. doi: 10.1186/s13046-018-0747-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — SPRY4-IT1 promotes cell metastatic properties by reversing EMT. a The migration capacities were detected in HuCCT1 and RBE cells transfected with si-SPRY4-IT1–1, si-SPRY4-IT1–2 or si-NC by wound healing assays. b-c The migration and invasive capacities were detected in HuCCT1 and RBE cells transfected with si-SPRY4-IT1–1, si-SPRY4-IT1–2 or si-NC by transwell assays. d E-cadherin, Snail, vimentin, Bcl-2 and Bax protein levels were detected in HuCCT1 and RBE cells transfected with si-SPRY4-IT1–1, si-SPRY4-IT1–2 or si-NC by western blotting. *P < 0.05, **P < 0.01