Fig. 4.

a, b Number of TSVs and non-fusion-gene TSVs in each sample in different cancer types. BRCA has slightly more samples with a larger number of (non-fusion-gene) TSVs. Thus, it has a longer tail on the y-axis. c, d Number of inter-chromosomal and intra-chromosomal TSVs within all TSVs and within non-fusion-gene TSVs. Non-fusion-gene TSVs contain more intra-chromosomal events than fusion-gene TSVs. (e) For breakpoints occurring more than 3 times in the same cancer type, the distribution of the entropy of its TSV partner. The lower the entropy, the more likely it is that the breakpoint has a fixed partner. The peak near 0 indicates a large portion of breakpoints are likely to be rejoined with the same partner in the TSV. However, there are still some breakpoints that have multiple rejoined partners. BLCA bladder urothelial carcinoma, BRCA breast invasive carcinoma, LUAD lung adenocarcinoma, PRAD prostate adenocarcinoma, TSV transcriptomic structural variant