Table 2.
Adjusted OR for the CKD according to genotype, dominant model and allele of MnSOD Val16Ala genotype
| Polymorphism | Genotype | CKD N (%) | Non-CKD N (%) | OR (95% CI) | P Value |
|---|---|---|---|---|---|
| MnSOD Val16Ala (rs4880) | Genotype | ||||
| Val/Val | 85 (30.4%) | 57 (20.4%) | 1 (ref.) | ||
| Ala/Val | 158 (56.4%) | 161 (57.5%) | 0.65 (0.44–0.98) | 0.041 | |
| Ala/Ala | 19 (6.8%) | 42 (15%) | 0.30 (0.16–0.57) | 0.001 | |
| Dominant Genotype Model | |||||
| Val/Val | 177 (63.2%) | 203 (72.5%) | 1 (ref.) | 0.006 | |
| Ala/Ala + Ala/Val | 85 (30.4%) | 57 (20.4%) | 0.55 (0.36–0.84) | ||
| Allele | |||||
| Val | 328 (62.6%) | 275 (52.88%) | 1 (ref.) | 0.004 | |
| Ala | 196 (37.4%) | 245 (47.12%) | 0.53 (0.35–0.82) | ||
ORs (odds ratios and 95% confidence intervals) were calculated using multivariate logistic regression analysis adjusted for BMI, energy intake, total Cholesterol, LDL-Cholesterol, triglyceride, Systolic and Diastolic blood pressure, smoking status and medication; CKD chronic kidney disease. CKD was defined as estimated glomerular filtration rate < 60 ml/min/1.73 m2. eGFR estimated glomerular filtration rate, MnSOD Manganese superoxide dismutase