Table 3.
Adjusted OR for the CKD according to quartile (Q) classification of TAC by the genotype and dominant model of MnSOD Val16Ala genotype
| MnSOD Val16Ala (rs4880) | OR (95% CI) quartiles | P for trend | P for interaction | |||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | |||
| Genotype | ||||||
| Val/Val (n = 142) | 1 (ref.) | 1.79 (0.66–4.83) | 2.02 (0.71–5.72) | 0.97 (0.36–2.6) | 0.055 | 0.082 |
| Ala/Val (n = 319) | 2.33 (1.18–4.59) | 3.48 (1.83–6.63) | 6.38 (3.33–13.2) | 4.47 (2.64–7.58) | 0.063 | |
| Ala/Ala (n = 61) | 1.58 (0.33–7.55) | 4.75 (0.99–22.67) | 4.75 (0.91–24.55) | 1.78 (1.06–2.99) | 0.133 | |
| Dominant Model | ||||||
| Val/Val (n = 142) | 1 (ref.) | 1.79 (0.66–4.83) | 2.02 (0.71–5.72) | 0.97 (0.36–2.6) | 0.055 | 0.254 |
| Ala/Ala+Ala/Val (n = 380) | 1.98 (0.82–4.78) | 1.13 (0.48–2.65) | 0.66 (0.28–1.59) | 0.3 (0.12–0.72) | 0.002 | |
ORs (odds ratios and 95% confidence intervals) were calculated using the conditional logistic regression model, adjusted for BMI, energy intake, total Cholesterol, LDL-Cholesterol, triglyceride, Systolic and Diastolic blood pressure, smoking status and medication. The lowest quartile of serum TAC and homozygote genotype with major allele (Val/Val) were used as the reference group