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. 2018 Apr 11;12:52. doi: 10.1186/s12918-018-0578-6

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — HSIN3.0 and HSIN.0_MC. The networks were spatially represented using the Cytoscape Prefuse Force Directed Layout. This program “is based on a” force-directed “paradigm. Network nodes are treated like physical objects that repel each other, such as electrons. The connections between nodes are treated like metal springs attached to the pair of nodes. These springs repel or attract their end points according to Functional in force function. The layout algorithm sets the positions of the nodes in a way that Minimizes the sum of forces in the network” (Cytoscape 3.4.0 User Manual http://manual.cytoscape.org/en/stable/index.html). The node diameter is directly proportional to the degree node and the node color gradient was dependent from the clustering coefficient, from red (higher) to green (lower)