Table 3.

phenotypical effects of the deletion of gene relative to protein listed in HSIN3.0_MC in KO mice on male fertility

	Hubs N (%)	Non-hubs N (%)
Male infertility	5 (23.8)	96 (27.8)
Male hypofertility	3 (14.3)	60 (17.4)
Male fertility affected	3 (14.3)	95 (27.5)
Male fertility unaffected/normal phenotype	10 (47.6)	94 (27.2)
Total	21 (100)	345 (100)

Male infertility: male KO is infertile; Male hypofertility: male KO has reduced fertility in comparison with wild type; Male fertility affected: KO mice have a damage in reproductive function with unclear or unknown effects on male fertility; Male fertility unaffected/normal phenotype: the KO mice have the same fertility of wild type