Table 3.

Scale up conditions^a (A t-amyl alcohol was removed under reduced pressure then extracted with the stated solvent. B poured onto water then extracted with the stated solvent. C solvent added to the microwave vial then sonicated to break up the reaction mixture then filtered and washed with the solvent. The filtrate was concentrated under reduced pressure. D t-amyl alcohol removed under reduced pressure and the solid was triturated with the stated solvent and the filtrate concentrated under reduced pressure).

Entry	Work up	Solvent	Yield 2b (%)	Yield 3c (%)
1	A	EtOAc	37	5
2	B	Et2O	36	5
3	C	EtOAc	38	5
4	C	Et2O	88	2
5	C	CH2Cl2	40	5
6	D	EtOAc	60	5
7	D	CH2Cl2	42	5
8d	D	Et2O	65	3

^aReactions conducted using 0.28 mmol of 1 and 1.4 mmol of CsF in 5 mL of t-amyl alcohol.

^bIsolated yield.

^cDetermined by 1H NMR.

^dReaction conducted with 1.4 mmol of 1, and 7 mmol of CsF in 5 mL of t-amyl alcohol.