Figure 5.
Upregulation of T, NK, and B Cell-Related Genes Characterizes the Secondary Response to Vincristine
(A) Expression changes in B1, B2, or B3 of 88 progressive immunological genes in CTVT-5 and CTVT-6.
(B) Diagram showing 10 representative nodes obtained by IPA using the 88 progressive immunological genes upregulated in CTVT-5. Key nodes are shown in blue; key genes belonging to the core signature of regression are shown in red; progressive up genes in common between CTVT-5 and the regressive 7xx CTVTs are shown in purple.
(C) The 88 immunological genes were annotated manually using Genecards and the available literature into four groups: I, inflammation/innate immunity; T, T cells; NK, natural killer cells; and B, B cells. Fold upregulation of genes in the S and R phase is relative to the P phase and is based on the normalized RNA-seq reads.