Figure 6.

Downregulated Genes Show a Melanoma-like Signature

(A) Pie charts indicating the relative proportion of each functional IPA network within the progressive and late downregulated gene groups of CTVT-5 and within the downregulated gene groups of the regressing 7xx CTVTs. Note that no early downregulated gene was detected in CTVT-5.

(B) Plots showing the confidence value of the main functionally annotated pathways identified by IPA for the late downregulated gene group in each regressing CTVT. The p value (Fisher's exact test) for each pathway is shown on the x axis.

(C and D) Heatmaps of comparative IPA analyses showing the top 10 diseases and biofunction pathways (C) or canonical pathways (D) for each individual regressive CTVTs. Pathways are clustered based on significance (Fisher's exact test) and similarity.

See also Tables S7 and S8; Figures S3 and S4.