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. 2018 Apr 9;33(4):664–675.e4. doi: 10.1016/j.ccell.2018.02.009

Figure 2.

Figure 2

Crystal Structure of ChiLob 7/4 Fab' in Complex with CD40 Extracellular Domain

(A) The crystal structure of the CD40:ChiLob 7/4 Fab' complex shows the Fab' in gray (dark gray, heavy chain; light gray, light chain) and CD40 colored by CRD (blue, CRD1-A1; red, CRD1-B2; green, CRD2-A1; magenta, CRD2-B2; orange, CRD3-A1; cyan, CRD3-B2 [partial]).

(B) Interface, with structural elements removed for clarity. Shown are the CDR loops of ChiLob 7/4 in red for CDR1, green for CDR2, and blue for CDR3. Light color shades represent the light chain, dark shades the heavy chain. CD40 colored as in (A) (translucent). See also Table S1.