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Comparing the inhibitory activity of the acids and hydroxamic acids.
| Structure | Type | Code | IC50 on MMP-2 (μM) | Structure | Type | Code | IC50 on MMP-2 (μM) |
|---|---|---|---|---|---|---|---|
 |
hydroxamic acid | AMRI-101H | 12 |  |
carboxylic acid | AMRI-101A/MMPI-1157 | 3.4 |
 |
hydroxamic acid | AMRI-102H | 11 |  |
carboxylic acid | AMRI-102A | 6.2 |
 |
hydroxamic acid | AMRI-103H | 17.6 |  |
carboxylic acid | AMRI-103A | 7.6 |
