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. 2018 Apr 5;9:296. doi: 10.3389/fphar.2018.00296

Table 2.

Results of thiazole carboxylic acid (TCA) and imidazole carboxylic acids (ICA) and related analogs.

Structure Code IC50 on MMP-1 (μM) IC50 on MMP-2 (μM) IC50 on MMP-9 (μM) IC50 on MMP-13 (μM) 3D alignment to 1157 cLogP
graphic file with name fphar-09-00296-i0007.jpg MMPI-1157 (TCA) 3.6 3.4 15 1.6 1.00 3.33
graphic file with name fphar-09-00296-i0008.jpg MMPI-1154 (ICA) 10 6.6 13 1.8 0.85 2.91
graphic file with name fphar-09-00296-i0009.jpg MMPI-1133 (TCA) 6.8 25 9,8 4.7 0.932 3.37
graphic file with name fphar-09-00296-i0010.jpg MMPI-1140 12 20 39 2.6 0.56 2.91
graphic file with name fphar-09-00296-i0011.jpg MMPI-1155 (TCA) 26 25 10 1.76 0.663 4.77
graphic file with name fphar-09-00296-i0012.jpg MMPI-1247 (ICA) 33 15 100 3.3 0.843 3.11
graphic file with name fphar-09-00296-i0013.jpg MMPI-1245 (ICA) 16 35 8 0.28 0.673 4.70
graphic file with name fphar-09-00296-i0014.jpg MMPI-1254 (TCA) 17 30 20 3 0.739 3.39
graphic file with name fphar-09-00296-i0015.jpg MMPI-1253 (TCA) 240 90 >500 8 0.927 2.22
graphic file with name fphar-09-00296-i0016.jpg MMPI-1252 (TCA) 115 54 >500 1.5 0.948 2.20
graphic file with name fphar-09-00296-i0017.jpg MMPI-1260 (TCA) 51 5.7 37 2.5 0.916 2.16
graphic file with name fphar-09-00296-i0018.jpg MMPI-1248 (TCA) 47 8 8.8 1.24 0.962 2.24