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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: J Am Chem Soc. 2018 Feb 22;140(9):3322–3330. doi: 10.1021/jacs.7b12768

Table 3.

Spin-Center Shift-Enabled Enantioselective α-Alkylation of Aldehydes with α-Acetoxy Ketonesa

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a

Acetate (0.5 mmol), aldehyde 45 (2.0 equiv), lutidine (50 mol %), lutidine·HOTf (20 mol %), organocatalyst 8 (20 mol %), and photocatalyst 18 (0.5 mol %) were irradiated in DMA with a 34 W blue LED lamp at 0 °C. Isolated yields are reported. Enantioselectivities were determined by chiral HPLC analysis.