Table 1.
Comparison of the Body Weight, Troponin-I, and Echocardiographic Parameters
Placebo | Single Bolus | Divided Dose | P value | |
---|---|---|---|---|
Weight, kg | 31.2±1.0 | 34.9±1.7 | 32.6±1.3 | 0.193 |
Troponin-I at Day 2, ng/mL | 96.4±25.5 | 90.0±18.7 | 108.6±5.1 | 0.695 |
LVEF before MI, % | 64.0±1.0 | 65.7±1.1 | 64.6±1.3 | 0.561 |
LVEF at Day 2, % | 41.0±1.1 | 41.7±0.7 | 39.6±0.8 | 0.162 |
LVEF at Day 28, % | 40.6±1.3 | 47.1±1.1 | 43.3±1.0 | 0.010 |
Change in LVEF from Day 0 to 2, % | -23.0±1.5 | -24.0±1.3 | -25.0±1.9 | 0.594 |
Change in LVEF from Day 2 to 28, % | -0.4±0.6 | 5.4±0.9 | 3.7±0.7 | 0.003 |
Anterior Wall Thickening at Day 28, % | 21.6±7.5 | 44.1±3.2 | 30.1±2.4 | 0.019 |
Inferior Wall Thickening at Day 28, % | 66.2±4.1 | 70.0±3.7 | 62.7±1.8 | 0.386 |
Anterior/Inferior Thickening Ratio at Day 28 | 31.5±10.2 | 63.2±4.0 | 47.8±3.3 | 0.012 |
Wall Motion Score Index (WMSI) at Day 2 | 1.71±0.21 | 1.70±0.18 | 1.74±0.25 | 0.949 |
Wall Motion Score Index (WMSI) at Day 28 | 1.70±0.17 | 1.38±0.11 | 1.35±0.12 | 0.001 |