Table 1. Applied parameters for preparation of paclitaxel loaded PLGA nanoparticles using single emulsion .
Number |
PLGA
(mg) |
Solvent
(ml) |
Drug
(mg) |
PVA
(W/V %) |
Sonication time
(min) |
Mean Size
(nm) |
1 | 20 | 3 | 1 | 1% | 4 | 250 ± 12 |
2 | 20 | 3 | 1.5 | 1% | 4 | 270 ± 22 |
3 | 20 | 3 | 3 | 1% | 4 | 353 ± 24 |
4 | 20 | 3 | 4.5 | 1% | 4 | 371 ± 39 |
5 | 20 | 3 | 6 | 1% | 4 | 402 ± 9 |
6 | 60 | 3 | 3 | 1% | 2 | 548 ± 10 |
7 | 60 | 3 | 3 | 1% | 4 | 303 ± 15 |
8 | 60 | 3 | 3 | 1% | 5 | 546 ± 17 |
9 | 60 | 3 | 3 | 1% | 6 | 598 ± 20 |
10 | 10 | 3 | 1.5 | 1% | 4 | 250 ± 15 |
11 | 30 | 3 | 1.5 | 1% | 4 | 327 ± 17 |
12 | 40 | 3 | 1.5 | 1% | 4 | 354 ± 12 |
13 | 50 | 3 | 1.5 | 1% | 4 | 381 ± 18 |
14 | 60 | 3 | 1.5 | 1% | 4 | 414 ± 21 |
15 | 30 | 1 | 1 | 1% | 4 | 478 ± 10 |
16 | 30 | 2 | 1 | 1% | 4 | 381 ± 12 |
17 | 30 | 3 | 1 | 1% | 4 | 300 ± 18 |
18 | 30 | 4 | 1 | 1% | 4 | 412 ± 21 |
19 | 30 | 5 | 1 | 1% | 4 | 469 ± 14 |
20 | 30 | 6 | 1 | 1% | 4 | 491 ± 11 |