Table 1.
β2*-nAChR occupancy, maximum arterial blood nicotine concentration, and area under the curve after use of 8 mg/ml EC, 36 mg/ml EC, and tobacco cigarette
| Subject No. | % Receptor occupancy after 8 mg/ml EC | % Receptor occupancy after 36 mg/ml EC | % Receptor occupancy after TOBACCO cigarette | V ND average (ml/cm 3 ) | C max (ng/ ml) after 8 mg/ml EC | C max (ng/ ml) after 36 mg/ml EC | C max (ng/ml) after TOBACCO cigarette | T max (min) after 8 mg/ml EC | T max (min) after 36 mg/ ml EC | T max (min) after TOBACCO cigarette | AUC after 8 mg/ ml EC (ng*min/ml) | AUC after 36 mg/ml EC (ng*min/ml) | AUC after TOBACCO cigarette (ng*min/ml) | Average [NIC] 60–90 min after 8 mg/ml EC | Average [NIC] 60–90 min after 36 mg/ml EC | Average [NIC] 60–90 min after TOBACCO cigarette |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 41.6 | 83.6 | N/A | 6.00 | 2.9 | 17 | N/A | 3 | 5 | N/A | 123.7 | 457.9 | N/A | 0 | 2.7 | N/A |
| 2 | 64.3 | 80.2 | N/A | 6.30 | 4.2 | 5.9 | N/A | 5 | 5 | N/A | 61.5 | 224.4 | N/A | 0 | 1.9 | N/A |
| 3 | 80.9 | 88.6 | N/A | 6.27 | 11.1 | 12.5 | N/A | 5 | 5 | N/A | 389.5 | 537.0 | N/A | 2.7 | 3.7 | N/A |
| 4 | 70.2 | 84.0 | N/A | 6.77 | 5.9 | 13.1 | N/A | 5 | 5 | N/A | 126 | 336.0 | N/A | 0.5 | 2.1 | N/A |
| 5 | N/A | N/A | 88.9 | 6.79 | N/A | N/A | 29.3 | N/A | N/A | 5 | N/A | N/A | 625.2 | N/A | N/A | 4.0 |
| 6 | N/A | N/A | 52.9 | 5.67 | N/A | N/A | 25.3 | N/A | N/A | 5 | N/A | N/A | 498.3 | N/A | N/A | 2.7 |
| 7 | N/A | N/A | 63.3 | 7.43 | N/A | N/A | 26.7 | N/A | N/A | 5 | N/A | N/A | 425.3 | N/A | N/A | 2.1 |
| AVERAGE | 64.3 ± 17 | 84.1 ± 3 | 68.4 ± 18 | 6.46 ± 0.58 | 6 ± 4 | 12 ± 5 | 27 ± 2 | 4.5 ± 1 | 5 ± 0 | 5 ± 0 | 175 ± 146 | 389 ± 137 | 516 ± 101 | 1.2 ± 1.7 | 2.2 ± 1.4 | 2.9 ± 0.97 |