Table 2.

List of Clinically Relevant Risk Markers Reported in the Present Manuscript and Timing of Measurement

Variable	Matrix	Screening	Confinement period								Ambulatory period
		Day −30 to −3	−2	−1	0	1	2	3	4	5	6	30	31	60	61	90	91
Safety-related variables
Vital signs		●	●	●	●	●	●	●	●	●	●	●		●			●
Body height and weight		●	●								●	●		●			●
Waist circumference			●														●
Hematology, clinical chemistry, urinalysis	Blood/urine	●			●						●		●		●		●
Biomarkers of exposure
COHb	Blood			●	●	●	●	●	●	●		●		●		●
Urinary biomarkers of exposure	Urine			●	●	●	●	●	●	●		●		●		●
Risk markers and other clinical markers
hs-CRP, fibrinogen, homocysteine, LDL cholesterol, HDL cholesterol	Blood				●								●		●		●
sICAM-1	Blood				●						●		●		●		●
HbA1c	Blood				●												●
8-epi-PGF2α and 11-DTX-B2	Urine				●					●		●		●		●

COHb = carboxyhemoglobin; HbA1c = hemoglobin A1c; HDL = high-density lipoprotein; hs-CRP = high-sensitivity C-reactive protein; LDL = low-density lipoprotein; sICAM-1 = soluble intercellular adhesion molecule-1; 8-epi-PGF2α = 8-epi-prostaglandin F2α; 11-DTX-B2 = 11-dehydro-thromboxane B2. The other variables assessed in this study are listed in the accompanying publication. Only results at baseline (Day 0) and Day 90/91 are reported here.