Table 1.
Effect of Nicotine on Expression of Genes Related to Drug Addiction and Novelty-Seeking Behavior in the Nucleus Accumbens of F344 and HIV-1Tg Rats
| Gene symbol | F344 rat | HIV-1Tg rat | Viral effect | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Saline (Mean ± SD) | Nicotine (Mean ± SD) | Ratio (Nic/Sal) | p | Saline (Mean ± SD) | Nicotine (Mean ± SD) | Ratio (Nic/Sal) | p | Ratio (HIV-1Tg/F344) | p | |
| Drd5 | 0.00046 ± 0.000229 | 0.000348 (0.000236) | 0.757 | .660 | 0.000203 ± 5.11E-05 | 0.000472 ± 0.000157 | 2.325 | .002 | 0.441 | .025 |
| Gabra1 | 0.1380 ± 0.0941 | 0.1231 ± 0.0892 | 0.892 | .785 | 0.0888 ± 0.0117 | 0.1741 ± 0.0534 | 1.961 | .007 | 0.643 | .280 |
| Gabra2 | 0.1926 ± 0.0535 | 0.2217 ± 0.0296 | 1.151 | .272 | 0.1491 ± 0.0108 | 0.1212 ± 0.0133 | 0.813 | .012 | 0.774 | .154 |
| Gabra5 | 0.0170 ± 0.0041 | 0.0363 ± 0.0035 | 2.135 | .0001 | 0.0229 ± 0.0074 | 0.0205 ± 0.0150 | 0.895 | .724 | 1.347 | .186 |
| Gabra6 | 0.000153 ± 0.0001 | 0.000202 ± 0.000135 | 1.320 | .490 | 0.000169 ± 3.49E-05 | 0.000334 ± 9.74E-05 | 1.976 | .007 | 1.105 | .950 |
| Grm1 | 0.0248 ± 0.0112 | 0.0213 ± 0.0019 | 0.859 | .512 | 0.0181 ± 0.0040 | 0.0250 ± 0.0027 | 1.381 | .011 | 0.730 | .197 |
| Grm5 | 0.1730 ± 0.0421 | 0.1620 ± 0.0414 | 0.936 | .658 | 0.1663 ± 0.0337 | 0.1162 ± 0.0211 | 0.699 | .012 | 0.961 | .770 |
Significant p values shown in boldface type.