Table 2.
Effect of Nicotine on Expression of Genes Related to Drug Addiction and Novelty-Seeking Behavior in the Prefrontal Cortex of F344 and HIV-1Tg Rats
| Gene symbol | F344 rat | HIV-1Tg rat | Viral effect | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Saline (Mean ± SD) | Nicotine (Mean ± SD) | Ratio (Nic/Sal) | p | Saline (Mean ± SD) | Nicotine (Mean ± SD) | Ratio (Nic/Sal) | p | Ratio (HIV-1Tg/F344) | p | |
| Drd1a | 0.00340 ± 0.001 | 0.00321 ± 0.000748 | 0.944 | .723 | 0.0034 ± 0.0001 | 0.0024 ± 0.0004 | 0.717 | .010 | 1.00 | .951 |
| Drd2 | 0.000143 ± 2.46E-05 | 0.000180 ± 4.81E-05 | 1.259 | .189 | 0.000296 ± 0.000139 | 0.000133 ± 1.92E-05 | 0.449 | .032 | 2.07 | .070 |
| Drd3 | 1.80E-05 ± 8.58E-06 | 2.27E-05 ± 1.04E-05 | 1.261 | .439 | 4.37E-05 ± 1.63E-05 | 2.66E-05 ± 6.59E-06 | 0.609 | .038 | 2.43 | .011 |
| Drd5 | 0.000102 ± 6.62E-05 | 7.78E-05 ± 2.34E-05 | 0.763 | .406 | 7.94E-05 ± 1.46E-05 | 4.06E-05 ± 1.61E-05 | 0.511 | .007 | 0.778 | .514 |
| Gabra3 | 0.0398 ± 0.00880 | 0.0534 ± 0.00974 | 1.342 | .040 | 0.0409 ± 0.00694 | 0.0410 ± 0.00785 | 1.002 | .973 | 1.028 | .836 |
| Gabra5 | 0.0430 ± 0.00973 | 0.0381 ± 0.00678 | 0.886 | .337 | 0.0470 ± 0.0200 | 0.0247 ± 0.00263 | 0.526 | .037 | 1.093 | .672 |
| Grm2 | 0.0084 ± 0.0017 | 0.0150 ± 0.00145 | 1.788 | .0001 | 0.0134 ± 0.00282 | 0.0190 ± 0.00441 | 1.418 | .026 | 2.262 | .014 |
Significant p values shown in boldface type.