Table 3.
Effect of Nicotine on Expression of Genes Related to Drug Addiction and Novelty-Seeking Behavior in the Ventral Tegmental Area of F344 and HIV-1Tg Rats
| Gene symbol | F344 rat | HIV-1Tg rat | Viral effect | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Saline (Mean ± SD) | Nicotine (Mean ± SD) | Ratio (Nic/Sal) | p | Saline (Mean ± SD) | Nicotine (Mean ± SD) | Ratio Nic/Sal) | p | Ratio (HIV-1Tg/F344) | p | |
| Drd5 | 0.000667 ± 0.000336 | 0.000496 ± 0.000122 | 0.744 | .267 | 0.0014 ± 0.0002 | 0.000658 ± 0.000248 | 0.470 | .002 | 2.099 | .005 |
| Gabra6 | 7.06E-05 ± 4.84E-05 | 0.000306 ± 0.000204 | 4.334 | .022 | 0.000274 ± 0.000117 | 0.000122 ± 9.27E-05 | 0.445 | .040 | 3.824 | .006 |
| Grm1 | 0.0228 ± 0.0043 | 0.0114 ± 0.0042 | 0.500 | .002 | 0.0236 ± 0.0062 | 0.0168 ± 0.0035 | 0.712 | .041 | 1.035 | .791 |
| Grm2 | 0.0156 ± 0.0081 | 0.0060 ± 0.0045 | 0.385 | .029 | 0.0167 ± 0.0048 | 0.0110 ± 0.0025 | 0.659 | .033 | 1.071 | .952 |
| Grm5 | 0.0397 ± 0.0050 | 0.0339 ± 0.0173 | 0.854 | .451 | 0.0589 ± 0.0269 | 0.0273 ± 0.0064 | 0.463 | .020 | 1.484 | .321 |
Significant p values shown in boldface type.