Table 2.
Summary of breakthrough yeast bloodstream infections in patients with hematological malignancies.
| Patients No. | Sex/age | Underlying hematological malignancy | Existing antifungal agent | Source | Yeast species | Susceptibility to existing antifungal agent | First-line antifungal agent | Outcome at 6 weeks |
|---|---|---|---|---|---|---|---|---|
| 1 | M/48 | Acute leukemia | Micafungin | CVC | Candida krusei | Unknown | Amphotericin B | Died |
| 2 | F/60 | Lymphoma | Fluconazole | Unknown | Candida krusei | Resistant | Amphotericin B | Survived |
| 3 | M/54 | Acute leukemia | Amphotericin B | GI tract | Candida krusei | Unknown | Caspofungin | Survived |
| 4 | M/43 | Myelodysplastic syndrome | Amphotericin B | CVC | Saccharomyces cerevisiae | Susceptible | Caspofungin | Survived |
| 5 | M/63 | Multiple myeloma | Itraconazole | CVC | Candida albicans Candida dubliniensis | Susceptible | Amphotericin B | Died |
| 6 | M/68 | Acute leukemia | Fluconazole | GI tract | Candida krusei | Resistant | Amphotericin B | Survived |
| 7 | M/46 | Acute leukemia | Fluconazole | Unknown | Candid tropicalis | Susceptible | Amphotericin B | Died |
| 8 | M/68 | Myelodysplastic syndrome | Amphotericin B | CVC | Candida pelliculosa | Unknown | Amphotericin B | Survived |
| 9 | F/51 | Myelodysplastic syndrome | Fluconazole | GI tract | Candida guillermondii | Susceptible | Amphotericin B | Died |
| 10 | F/54 | Lymphoma | Fluconazole | GI tract | Candida glabrata | Resistant | Caspofungin | Survived |
| 11 | M/42 | Acute leukemia | Fluconazole | GI tract | Candida krusei | Resistant | Amphotericin B | Survived |
| 12 | F/62 | Acute leukemia | Fluconazole | CVC | Candida albicans | Unknown | Amphotericin B | Survived |
| 13 | F/53 | Acute leukemia | Fluconazole | CVC | Candida krusei | Resistant | Amphotericin B | Survived |
| 14 | M/56 | Acute leukemia | Posaconazole | GI tract | Candida glabrata | Susceptible | Caspofungin | Survived |
| 15 | F/54 | Myelodysplastic syndrome | Itraconazole | CVC | Trichosporon asahii | Resistant | Voriconazole | Survived |
| 16 | M/29 | Severe aplastic anemia | Fluconazole | GI tract | Candida albicans | Susceptible | Caspofungin | Survived |
| 17 | M/51 | Acute leukemia | Caspofungin | Unknown | Pseudozyma aphidis | Resistant | Caspofungin | Survived |
| 18 | F/73 | Acute leukemia | Itraconazole | CVC | Candida krusei | Resistant | Amphotericin B | Died |
| 19 | F/51 | Acute leukemia | Fluconazole | CVC | Candida inconspicua | Resistant | Caspofungin | Survived |
| 20 | M/69 | Acute leukemia | Fluconazole | Unknown | Candida glabrata | Resistant | Amphotericin B | Died |
| 21 | M/56 | Acute leukemia | Caspofungin | Unknown | Candida glabrata | Susceptible | Amphotericin B | Died |
CVC, central venous catheter; GI, gastrointestinal.