Table 1.
Main Effects, Two-way, and Three-way Interactions for Each Regional Coupling
| Regional coupling | Strain | Time | Drug | Strain × drug | Strain × time | Drug × time | Strain×drug × time | |
|---|---|---|---|---|---|---|---|---|
| VTA-SN | F | / | / | / | / | / | 4.082 | 3.356 |
| p | / | / | / | / | / | .050 | .045 | |
| VTA-IPN | F | / | / | / | / | 3.23 | / | / |
| p | / | / | / | / | .050 | / | / | |
| VTA-CPu | F | / | / | / | 4.998 | / | / | / |
| p | / | / | / | .011 | / | / | / | |
| VTA-MH | F | / | / | 23.872 | / | / | / | / |
| p | / | / | < .001 | / | / | / | / | |
| RSP-VTA | F | / | / | / | / | / | / | 3.667 |
| p | / | / | / | / | / | / | .034 | |
| RSP-INS | F | / | / | / | / | 5.029 | / | / |
| p | / | / | / | / | .011 | / | / | |
| RSP-Acc | F | 4.456 | / | 4.155 | 3.670 | 5.609 | / | / |
| p | .018 | / | .048 | .034 | .007 | / | / | |
| RSP-PL | F | 6.377 | / | / | / | 5.019 | / | / |
| p | .004 | / | / | / | .011 | / | / | |
| RSP-HP | F | / | 7.982 | 7.268 | 5.375 | / | / | / |
| p | / | .007 | .010 | .008 | / | / | / | |
| RSP-CPu | F | / | / | / | / | 4.481 | / | / |
| p | / | / | / | / | .017 | / | / | |
| RSP-MH | F | / | / | / | 3.539 | 3.717 | 10.818 | / |
| p | / | / | / | .038 | .033 | .002 | / | |
| AMG-RSP | F | 3.396 | / | / | / | / | / | / |
| p | .043 | / | / | / | / | / | / | |
| AMG-VTA | F | 5.408 | / | / | / | 6.202 | 7.227 | / |
| p | .008 | / | / | / | .004 | .010 | / | |
| AMG-CPu | F | / | 7.634 | 5.570 | / | 13.212 | 7.431 | / |
| p | / | .009 | .023 | / | < 0.001 | .009 | / | |
| AMG-MH | F | / | 4.565 | / | / | / | / | / |
| p | / | .039 | / | / | / | / | / | |
| INS-Acc | F | / | 5.476 | / | / | / | / | / |
| p | / | .024 | / | / | / | / | / | |
| INS-ILA | F | / | / | 5.212 | / | / | / | / |
| p | / | / | .028 | / | / | / | / | |
| INS-SN | F | / | / | 9.768 | / | 3.279 | / | / |
| p | / | / | .003 | / | .048 | / | / | |
| Acc-ILA | F | / | 4.75 | / | / | / | / | / |
| p | / | .035 | / | / | / | / | / | |
| Acc-NAcc | F | / | 6.012 | / | / | / | / | / |
| P | / | .019 | / | / | / | / | / | |
| Acc-CPu | F | / | 10.824 | / | / | / | / | / |
| p | / | .002 | / | / | / | / | / | |
| ILA-SN | F | / | 4.417 | / | / | / | / | / |
| p | / | .042 | / | / | / | / | / | |
| ILA-NAcc | F | 10.821 | / | / | 4.210 | / | / | / |
| p | < .0010 | / | / | .022 | / | / | / | |
| ILA-PL | F | 5.329 | / | / | 5.510 | / | / | / |
| p | .009 | / | / | .008 | / | / | / | |
| NAcc-VTA | F | / | / | / | 5.057 | / | / | / |
| p | / | / | / | .011 | / | / | / | |
| NAcc-PL | F | 5.323 | 9.22 | / | / | / | / | / |
| p | .009 | .004 | / | / | / | / | / | |
| NAcc-HP | F | / | / | / | / | / | 4.497 | / |
| p | / | / | / | / | / | .040 | / | |
| PL-CPu | F | / | 5.765 | / | / | / | / | / |
| p | / | .021 | / | / | / | / | / | |
| PL-IPN | F | / | 4.956 | / | / | 6.367 | 16.454 | / |
| p | / | .032 | / | / | .004 | < .0010 | / | |
| PL-MH | F | 4.333 | / | / | / | / | / | / |
| p | .020 | / | / | / | / | / | / | |
| SN-MH | F | / | / | 8.899 | / | / | / | / |
| p | / | / | .005 | / | / | / | / | |
| MH-IPN | F | / | / | 5.171 | / | / | / | / |
| p | / | / | .028 | / | / | / | / | |
PL = prelimbic area; ILA = infralimbic area; ACC = anterior cingulate cortex; NAcc, nucleus accumbens; VTA = ventral tegmental area; INS = insula, AMG = amygdala; RSP = retrosplenial cortex; HP = hippocampus; CPu = caudoputamen; SNr = substantia nigra; VIS = visual cortex; SI = substantia innominata/ventral pallidum; MH = medial habenula; IPN = interpeduncular nucleus. F-value of ANOVA; p, statistical probability, unadjusted for multiple testing; /: p > .05.