Table 2.

Association of rs16969968 and Chromosome 15 CHRNA5/A3/B4 SNPs With Heavy/Light Smoking in HCHS/SOL

rsID	bp	Gene	Function	Qualitya	Effect allele/ref allele	Effect allele freq	Primary heavy/light (>10 vs. ≤ 10)		Primary heavy/light (> 10 vs ≤ 10) conditioned on rs16969968
							OR (95% CI)	p	OR (95% CI)	p
rs16969968	78882925	CHRNA5	Non-syn	1	A/G	0.219	1.32 (1.19–1.46)	2.20E-7	—	—
rs1051730	78894339	CHRNA3	Syn	1	A/G	0.231	1.34 (1.21–1.49)	1.74E-08	1.64 (1.10–2.45)	.014739
rs4243084	78911672	CHRNA3/B4	Intronic	0.998	C/G	0.269	1.32 (1.20–1.45)	1.78E-08	1.26 (1.03–1.54)	.022103
rs58365910	78849034	CHRNA5	Intergenic	0.994	C/T	0.245	1.33 (1.21–1.47)	2.00E-08	1.27 (1.03–1.57)	.025894
rs8040868	78911181	CHRNA3	Syn	1	C/T	0.317	1.30 (1.19–1.43)	2.16E-08	1.21 (1.04–1.40)	.011916
—	78898675			0.887	Indel	0.385	1.31 (1.19–1.44)	2.21E-08	1.21 (1.06–1.38)	.006382
—	78913353	CHRNA3		0.89	Indel	0.363	1.30 (1.19–1.43)	2.66E-08	1.20 (1.05–1.37)	.76013
—	78871382	CHRNA5	Intronic	0.796	Indel	0.281	1.32 (1.20–1.46)	3.12E-08	1.21 (1.04–1.41)	.657196
rs55676755	78898932	CHRNA3	Intronic	0.999	G/C	0.237	1.33 (1.20–1.48)	3.24E-08	1.38 (1.00–1.69)	.052231
rs12914385	78898723	CHRNA3	Intronic	1	T/C	0.263	1.32 (1.20–1.45)	3.32E-08	1.24 (1.01–1.54)	.042405
—	78859605	CHRNA5	Intronic	0.988	Indel	0.241	1.33 (1.20–1.47)	4.01E-08	1.27 (0.99–1.64)	.062451
rs190065944	78859610	CHRNA3	Intronic	1	A/G	0.239	1.33 (1.20–1.47)	4.15E-08	1.25 (0.99–1.58)	.058969
rs2036527	78851615	CHRNA5	Intergenic	1	A/G	0.237	1.33 (1.20–1.47)	4.29E-08	1.25 (0.99–1.57)	.059432
—	78899560	CHRNA3	Intronic	0.986	Indel	0.246	1.32 (1.20–1.46)	4.94E-08	1.28 (0.97–1.69)	.084076

CI = confidence interval; HCHS/SOL = Hispanic Community Health Study/Study of Latinos; OR = odds ratio.

^aImputation quality score (R²) is given (value 1 if genotyped).