Fig. 1. The chemical modifications used in this study. (a) 2′-Deoxythymidine (dT); (b) 2′-O-methyl-uridine (OMe); (c) phosphorothioate thymidine (PS); (d) β-l-2′-deoxythymidine (MIR); (e) 1,4-anhydro-2-deoxy-d-ribitol (RIB); (f) acridinyl-l-threoninol (ACR); (g) thymine glycol nucleic acid (GNA) and (h) l-threoninol-thymine (THR). The schematic representation of siRNA illustrates the nucleotide sequence, where X defines the position for chemical modification conjugation.
