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Time-course (minutes) showing the percentage of animals with analgesia after treatment with 0.5% BVC plain solution or encapsulated into alginate–chitosan nanoparticles (BVCALG) as evaluated by the infraorbital nerve blockade test in rats (n=7/group).
Abbreviations: BVC, bupivacaine; BVCALG, 0.5% bupivacaine-loaded alginate–chitosan nanoparticles.
