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Histological analysis of the upper right first molar oral mucosa in rats 24 hours after local anesthetic administration: (B) BVC; (D) BVCALG; (F) NPALG. The left side was respectively used as control: (A) control BVC; (C) control BVCALG; (E) control NPALG.
Notes: Observe the local tissue inflammation (rectangle). Scale bar: 100 µm.
Abbreviations: BVC, bupivacaine; BVCALG, 0.5% bupivacaine-loaded alginate–chitosan nanoparticles; NPALG, alginate/chitosan nanoparticle.
