. 2018 Apr 6;11:683–691. doi: 10.2147/JPR.S158695

Table 2.

Total effect of sensory blockade (AUC) and time for recovery for 0.5% BVC plain and BVC_ALG in rats

Groups	AUC (score/h)	Time for recovery (min)
NP_ALG	0	0
BVC	67.5 (62.5–77.5)	75 (70–85)
BVC_ALG	92.5 (87.5–97.5)^***	100 (95–105)^***

Notes: Statistical analysis: Mann–Whitney test,

^***

p<0.001 BVC versus BVC_ALG. Data are expressed as median (minimum–maximum) (n=7/group).

Abbreviations: BVC, bupivacaine; BVC_ALG, 0.5% bupivacaine-loaded alginate–chitosan nanoparticles; AUC, area under the curve; NP_ALG, alginate/chitosan nanoparticle.