Table 1.
Main information of the included studies in the meta-analysis
| Study | Country | Ethnicity | Patients (n) |
Male n (%) |
Age (years) | Outcome | Analysis | Cut-off value | Therapy | NOS |
|---|---|---|---|---|---|---|---|---|---|---|
| Wang et al 201234 | China | Asian | 177 | 120 (67.8) | <65.0 (70.1%) | OS | U | 300 | NA | 7 |
| Stotz et al 201333 (1) | Austria | Caucasian | 261 | 103 (39.5) | <65.0 (42.5%) | OS | U | 150 | NA | 6 |
| Stotz et al 201333 (2) | Austria | Caucasian | 110 | 51 (46.4) | <65.0 (50.0%) | OS | U | 150 | Surgery | 6 |
| Martin et al 201431 | Australia | Caucasian | 124 | 66 (53.2) | 68.5 (35–90) | OS | M | 200 | NA | 7 |
| Qi et al 201532 | China | Asian | 211 | 134 (63.5) | <60.0 (75.4%) | OS | M | 126 | NA | 7 |
| Goh et al 201527 | Singapore | Asian | 120 | 49 (40.8) | 60.5 (24–84) | OS | M | 208.1 | NA | 8 |
| Inoue et al 201528 | Japan | Asian | 440 | 249 (56.6) | 67.0 (32–88) | OS | U | 150 | NA | 6 |
| Kishi et al 201520 | Japan | Asian | 65 | 39 (60.0) | 65.0 (35–85) | OS, DFS | U | 150 | Chemoradiotherapy | 7 |
| Shirai et al 201521 | Japan | Asian | 131 | 81 (61.8) | 66.5±10.2a | OS, DFS | M | 150 | Surgery | 6 |
| Spolverato et al 201522 | USA | Caucasian | 420 | 208 (49.5) | NA | OS, RFS | M | 190 | Surgery | 8 |
| Alagappan et al 201625 | USA | Caucasian | 208 | 109 (52.4) | 75.2 (65.9–86.1) | OS | U | 200 | Radiotherapy | 7 |
| Asari et al 201626 | Japan | Asian | 37 | 20 (54.0) | <70.0 (62.0%) | OS | M | 225 | Surgery | 6 |
| Lee et al 201629 | South Korea | Asian | 82 | 49 (60.0) | 63.5±10.7a | OS, PFS | U | 150 | Chemotherapy | 8 |
| Watanabe et al 201635 | Japan | Asian | 46 | 26 (56.5) | NA | OS | M | 200 | Surgery | 6 |
| Liu et al 201730 | China | Asian | 386 | 238 (61.7) | <65.0 (64.2%) | OS | U | 165.5 | NA | 6 |
| Yu et al 201736 (1) | China | Asian | 139 | 83 (59.7) | <60.0 (38.8%) | OS | U | 154 | Chemotherapy | 7 |
| Yu et al 201736 (2) | China | Asian | 225 | 146 (64.9) | <60.0 (34.7%) | OS | U | 154 | Chemotherapy | 6 |
Notes: (1) cohort I; (2) cohort II. Data presented as range unless otherwise indicated.
a
Data presented as mean ± SD.
Abbreviations: DFS, disease-free survival; M, multivariate analysis; NA, not available; NOS, Newcastle–Ottawa scale; OS, overall survival; PFS, progression-free survival; RFS, recurrence-free survival; U, univariate analysis.