Table 2.
Subgroup analysis of the association between the PLR expression and OS
| Survival analysis | Included cohorts | HR (95% CI) | P-value | I2 (%) | P-value for heterogeneity | Analysis model |
|---|---|---|---|---|---|---|
| Analysis model | ||||||
| Multivariate | 7 | 1.76 (1.45–2.14) | <0.00001* | 9 | 0.36 | Fixed |
| Univariate | 10 | 1.18 (1.07–1.30) | 0.001* | 0 | 0.57 | Fixed |
| Ethnicity | ||||||
| Caucasian | 5 | 1.25 (1.08–1.45) | 0.004* | 17 | 0.31 | Fixed |
| Asian | 12 | 1.35 (1.14–1.61) | 0.0006* | 52 | 0.02 | Random |
| Sample size | ||||||
| ≤150 | 9 | 1.49 (1.14–1.94) | 0.003* | 52 | 0.03 | Random |
| >150 | 8 | 1.26 (1.11–1.42) | 0.0003* | 31 | 0.18 | Fixed |
| Cut-off value | ||||||
| ≤150 | 7 | 1.19 (1.02–1.40) | 0.03* | 29 | 0.21 | Fixed |
| >150 | 10 | 1.39 (1.23–1.56) | <0.00001* | 43 | 0.07 | Fixed |
| Treatment | ||||||
| Surgery | 5 | 1.86 (1.22–2.84) | 0.004* | 63 | 0.029 | Random |
| Not surgery | 12 | 1.24 (1.13–1.36) | <0.00001* | 22 | 0.229 | Fixed |
Note:
*
P<0.05, the difference was statistically significant.
Abbreviations: HR, hazard ratio; OS, overall survival; PLR, platelet-to-lymphocyte ratio.