Table 3.

Result of a meta-regression analysis in patients with MDD and controls

Moderator	Number of association studies	Meta-regression analysis				Heterogeneity
		Slope	95% CI lower	95% CI upper	p-value	l2 (%)	Q (p-value)
Age (mean year)	10	0.0078	−0.027	0.042	0.66	82.3	<1.0×10−4
Gender (% male)	11	0.0006	−0.018	0.019	0.95	79.7	<1.0×10−4
Medication exposure (% medication-received patients)	10	−0.0018	−0.012	0.0083	0.73	74.8	1.2×10−4
Sample size	12	−0.0012	−0.0041	0.0017	0.42	72.2	2.4×10−4
Published year	12	−0.0018	−0.035	0.032	0.92	77.3	<1.0×10−4

Abbreviation: MDD, major depressive disorder.