. 2018 Apr 5;12:757–767. doi: 10.2147/DDDT.S156000

Table 7.

Meta-analysis results of total incidence rate and different influencing factors of ADRs

Analysis type	Studies	Total sample size	Number of ADR cases	Heterogeneity test	Effect models	Meta-analysis results
Analysis type	Studies	Total sample size	Number of ADR cases	Heterogeneity test	Effect models	Merger rate (%)	95% CI
Total incidence	64	3,222	213	I² = 36.8%, P = 0.0022	Fixed	0.0584	0.0499; 0.0674
Incidence of general ADR	61	3,088	202	I² = 36.5%, P = 0.003	Fixed	0.0577	0.0491; 0.0669
Incidence of severe ADR	5	236	11	I² = 0%, P = 0.5952	Fixed	0.0436	0.0188; 0.0760
5%–10% GS	22	1,198	71	I² = 10.6%, P = 0.3211	Fixed	0.0517	0.0387; 0.0662
0.9% NS	16	725	45	I² = 8.7%, P = 0.3545	Fixed	0.0560	0.0389; 0.0754
Treatment time ≤7 d	6	398	23	I² = 42.7%, P = 0.1203	Fixed	0.0514	0.0303; 0.0770
7 d < treatment time ≤14 d	40	1,913	117	I² = 18.3%, P = 0.1588	Fixed	0.0549	0.0442; 0.0664
Treatment time >14 d	17	811	71	I² = 52.2%, P = 0.0064	Fixed	0.0780	0.0593; 0.0986
Single medication	9	448	28	I² = 0%, P = 0.7465	Fixed	0.0569	0.0357; 0.0820
Combined medication	52	2,481	166	I² = 44.3%, P = 0.0005	Fixed	0.0616	0.0484; 0.0761
Dose ≤20 mL/d	56	2,806	176	I² = 28.7%, P = 0.0261	Fixed	0.0557	0.0468; 0.0652
Dose >20 mL/d	5	202	22	I² = 48.0%, P = 0.1037	Fixed	0.1015	0.0614; 0.1492
Indications	57	2,930	189	I² = 39.3%, P = 0.0016	Fixed	0.0566	0.0479; 0.0660
Super indications	7	292	24	I² = 0%, P = 0.4729	Fixed	0.0775	0.0474; 0.1131

Abbreviations: ADR, adverse drug reaction; GS, glucose solution; NS, sodium chloride solution.