Figure 3.

Pretreatment with 2.5% sevoflurane limits the myocardial infarct size and reduces cardiac enzyme release.

Notes: (A) Representative myocardial cross sections of TTC-stained hearts for the five groups (n=6, five slices per heart). Red-stained areas indicate viable tissue, and unstained pale areas indicate infarct tissue. (B) Myocardial infarct size of hearts in the five groups. (C–E) Total CK-MB, LDH, and cTnI release in coronary effluent after 2 h reperfusion. Values are expressed as mean ± SEM. **P<0.01 vs the sham group; ^‡P<0.01 vs the I/R group; ^##P<0.01 vs the SPC group.

Abbreviations: CK-MB, creatine kinase-MB, cTnI, cardiac troponin-I; I/R, ischemia–reperfusion; LDH, lactate dehydrogenase; PIGF, placental growth factor; SEM, standard error of the mean; SPC, sevoflurane preconditioning; TTC, triphenyl tetrazolium chloride.