Table 4.

Pharmacokinetic parameters of norquetiapine in rat (n=6) administered with NQ freebase solution and NQ freebase PLGA 502H microspheres

Parameter	NQ freebase solution	NQ freebase PLGA 502H microspheres
Cmax (ng/mL)	25.08±11.41	22.48±4.46
Tmax (h)	0.29±0.10	1.50±0.45
t1/2 (h)	5.05±1.40	172.79±23.79
AUC (ng⋅h/mL)	33.17±9.33	916.46±186.57
AUMC (ng⋅h2/mL)	43.40±9.80	45,421.86±14,766.68

Note: Data presented as mean ± SD.

Abbreviations: AUC, area under the curve; AUMC, area under the moment curve; NQ, N-desalkyl quetiapine; PLGA, poly(d,l-lactic-co-glycolic acid).