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. 2017 Apr 13;17(3):207–218. doi: 10.3727/105221617X695438

Figure 5.

Figure 5

Effect of a single treatment with KB2115 on serum transaminases and liver apoptosis. (A) Graph representing the levels of serum transaminases 18 and 24 h after treatment with a single IG dose of DMSO (5% in corn oil, Co) or KB2115 (12.5 μg/100 g b.w.). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were determined in blood samples collected from the abdominal aorta. (B) Apoptotic index (AI) and (C) representative microphotographs showing the presence of apoptotic bodies (ABs) indicated by the arrows (H&E: 40×). AI was calculated as the number of ABs per field at 40× magnification. At least 25 fields per rat liver were scored. Results were expressed as means ± SE of three rats per group. (D) Representative microphotographs showing immunostaining for the cleaved form of caspase 3 (CAS-3) in the liver of rats treated with the vehicle or a single dose of KB2115 (12.5 μg/100 g b.w.) and sacrificed 3 h later. Arrows indicate single CAS-3+ cells (20×).