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. 2015 Oct 13;25(22):5072–5077. doi: 10.1016/j.bmcl.2015.10.023

Table 1.

Peptidomimetic inhibitors of FIPV-3CLpro

Compd Structure %I (50 μM) %I (10 μM) %I (5 μM)
1 graphic file with name fx2.gif 54.8 ± 5.7 36.4 ± 0.4 30.1 ± 1.9
2 graphic file with name fx3.gif 39.2 ± 0.5 12.8 ± 2.2 15.6 ± 0.8
3 graphic file with name fx4.gif 52.3 ± 1.4 36.0 ± 3.9 31.3 ± 1.1
4 graphic file with name fx5.gif 55.6 ± 1.9 34.4 ± 2.9 32.7 ± 1.3
5 graphic file with name fx6.gif 17.6 ± 1.2 11.2 ± 3.4 2.9 ± 2.7
6 graphic file with name fx7.gif 99.7 ± 0.2 92.1 ± 4.3 89.8 ± 2.1
7 graphic file with name fx8.gif 99.4 ± 0.02 92.2 ± 1.4 85.8 ± 4.9
8 graphic file with name fx9.gif 94.7 ± 1.3 69.1 ± 1.7 53.7 ± 4.0
9 graphic file with name fx10.gif 82.5 ± 1.8 33.3 ± 0.2 26.9 ± 0.5
10 graphic file with name fx11.gif 97.0 ± 0.9 58.6 ± 3.9 37.0 ± 2.4
11 graphic file with name fx12.gif 66.3 ± 0.2 20.5 ± 1.9 13.4 ± 3.7