Table 3.

Minimum and Mean Hemoglobin Effect on Patient Fatigue (N=784)

	Model	Hb Concentration	Inpatient Fatigue Level			High Fatigue (FACIT<27)
			β	95% CI	p	OR	95% CI	p
Minimum Hemoglobin	1	Minimum Hb (continuous)	1.4	(0.4, 2.3)	0.005	0.9	(0.8, 1.0)	0.09
		7g/dL≤Hb<8g/dL*	−4.1	(−6.6, −1.7)	<0.001	1.9	(1.3, 2.8)	<0.001
		Hb<7g/dL*	−4.2	(−6.6, −1.6)	<0.001	1.5	(1.1, 2.2)	0.03
	2	Minimum Hb (continuous)	1.0	(−0.1, 2.0)	0.05	0.9	(0.8, 1.1)	0.41
		7g/dL≤Hb<8g/dL*	−3.9	(−6.3, −1.4)	0.02	1.9	(1.3, 2.7)	0.001
		Hb<7g/dL*	−3.2	(−5.7, −0.6)	0.02	1.3	(0.9, 1.9)	0.21
	Model	Hb Concentration	Inpatient Fatigue Level			High Fatigue (FACIT<27)
			β	95% CI	p	OR	95% CI	p
Mean Hemoglobin	1	Mean Hb (continuous)	0.22	(−1.0, 1.5)	0.71	1.0	(0.9, 1.2)	0.67
		8g/dL≤Hb<9g/dL#	−2.5	(−4.9, −0.1)	0.04	1.5	(1.0, 2.1)	0.03
		Hb<8g/dL#	−2.4	(−5.1, 0.4)	0.09	1.2	(0.8, 1.9)	0.3
	2	Mean Hb (continuous)	0.4	(−0.9, 1.6)	0.6	1.0	(0.9, 1.2)	0.3
		8g/dL≤Hb<9g/dL#	−2.5	(−4.9, −0.2)	0.04	1.5	(1.1, 2.2)	0.03
		Hb<8g/dL#	−2.4	(−5.1, 0.3)	0.08	1.3	(0.8, 1.9)	0.27

^*Hb≥8g/dL referent group

^#Hb≥9g/dL referent group

Linear/Logistic Regression Model 1: Adjusted for age, sex, time of minimum Hb relative to measurement of fatigue, comorbidities

Linear/Logistic Regression Model 2: Adjusted for age, sex, time of minimum Hb relative to measurement of fatigue, # of cbc’s drawn during hospitalization, comorbidities

Comorbidities: myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, dementia, chronic pulmonary disease, rheumatic disease, peptic ulcer disease, liver disease, diabetes, hemiplegia/paraplegia, renal disease, cancer, sickle cell anemia, gastrointestinal bleeding, depressive disorder