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. 2014 Dec 29;115:21–38. doi: 10.1016/j.antiviral.2014.12.015

Fig. 9.

Fig. 9

Discovery and design pipeline for SARS-CoV PLpro inhibitors 24 and 15g. Results of the primary high-throughput screen identified hit compounds 7724772 (a1) and 6577871 (a2). SAR diagrams for analogs of 7724772 (b1) and 6577871 (b2) (Ghosh et al., 2010, Ratia et al., 2008). Structures of potent, first-generation leads 24 (c1) and 15g (c2). X-ray crystal structures of 24 (d1) (PDB: 3E9S) and 15g (d2) (PDB: 3MJ5) bound to SARS-CoV PLpro highlighting the residues involved in binding each inhibitor. Hydrogen bonds are shown as dashed lines.