Table 2.
Entry | Substrate | QMA eluent | Fluoride pre-dissolution medium | RCC | n |
---|---|---|---|---|---|
1 | 1-B(OH)2 | KOTf/K2CO3 | no dissolution step | 10±2%a | 2 |
2 | 1-B(OH)2 | KOTf/K2CO3 | DMF | 43±0% | 3 |
3 | 1-B(OH)2 | KOTf/K2CO3 | substrate | 30±8% | 2 |
4 | 1-B(OH)2 | KOTf/K2CO3 | substrate + pyridine | 39±7% | 2 |
5 | 1-Bpin | KOTf/K2CO3 | DMF | 32±24% | 2 |
6 | 1-Bpin | KOTf/K2CO3 | substrate | 56±4% | 2 |
7 | 1-Bpin | KOTf/K2CO3 | substrate + pyridine | 53±12% | 2 |
8 | 1-B(OH)2 | triethylamine | no dissolution step | 34±7% | 2 |
9 | 1-B(OH)2 | triethylamine | DMF | 19±6% | 2 |
10 | 1-B(OH)2 | triethylamine | substrate | 23±9% | 2 |
11 | 1-B(OH)2 | triethylamine | substrate + pyridine | 21±2% | 2 |
Original conditions reported in reference 2.