TABLE 3.
Plasma concentrations of 17-alpha hydroxyprogesterone caproate according to genotype of cytochrome P450 single nucleotide polymorphisms
| CYP SNP | Genotype | N | Genotypicfrequencies | 17 OHP-C ng/mL median (25the75th percentile) | Estimatea | SE | P value |
|---|---|---|---|---|---|---|---|
| CYP3A4*22 (rs35599367) |
GG | 243 | 0.931 | 9.8 (8e12.4) | 0.0339 | 0.0823 | .68 |
| GA | 17 | 0.065 | 10.2 (7.1e16.5) | ||||
| AA | 1 | 0.004 | 10.9 (10.9e10.9) | ||||
| CYP3A4*1G (rs2242480) |
CC | 128 | 0.559 | 9.9 (8.2e12.3) | 0.0321 | 0.0416 | .44 |
| CT | 64 | 0.279 | 10.0 (7.2e12.5) | ||||
| TT | 37 | 0.162 | 10.0 (8.2e13.5) | ||||
| CYP3A4*1B (rs2740574) |
TT | 184 | 0.689 | 9.9 (8.4e12.4) | 0.0832 | 0.0476 | .08 |
| CT | 58 | 0.217 | 11.0 (8.3e13.6) | ||||
| CC | 25 | 0.094 | 9.8 (7.9e12.1) | ||||
| CYP3A5*3 (rs776746) |
CC | 154 | 0.592 | 9.9 (8.3e12.4) | 0.0318 | 0.0414 | .44 |
| CT | 73 | 0.281 | 10.0 (7.2e12.1) | ||||
| TT | 33 | 0.127 | 9.9 (8.4e13.3) |
SNP, single nucleotide polymorphism; 17 OHP-C, 17-alpha hydroxyprogesterone caproate.
a
Beta estimate, SE, and P value from test of general linear model of genotype in additive model predicting log 17OHP-C; analysis adjusted for prepregnancy body mass index, race, and treatment group.
Bustos et al. Association of CYP3A and PR SNPs and 17 OHP-C. Am J Obstet Gynecol 2017.