TABLE 4.
Frequency of spontaneous preterm birth by genotype of progesterone receptor single nucleotide polymorphisms
| PR SNP | Genotype | N | Genotypicfrequencies | SPTB, n (%) | OR (95% CI)a | P value |
|---|---|---|---|---|---|---|
| rs578029 | AA | 20 | 0.073 | 5 (25.0) | 0.8 (0.5e1.2) | .29 |
| AT | 115 | 0.419 | 28 (24.3) | |||
| TT | 139 | 0.507 | 43 (30.9) | |||
| rs471767 | AA | 140 | 0.509 | 45 (32.1) | 0.7 (0.4e1.1) | .10 |
| AG | 117 | 0.425 | 26 (22.2) | |||
| GG | 18 | 0.065 | 5 (27.8) | |||
| rs666553 | CC | 190 | 0.696 | 53 (27.9) | 0.9 (0.5e1.6) | .76 |
| CT | 78 | 0.285 | 21 (26.9) | |||
| TT | 5 | 0.018 | 0 (0.0) | |||
| rs503362 | CC | 14 | 0.051 | 3 (21.4) | 0.7 (0.4e1.1) | .09 |
| CG | 108 | 0.394 | 25 (23.1) | |||
| GG | 152 | 0.554 | 47 (30.9) | |||
| rs500760 | CC | 20 | 0.072 | 7 (35.0) | 1.2 (0.8e1.8) | .43 |
| CT | 119 | 0.432 | 33 (27.7) | |||
| TT | 136 | 0.494 | 36 (26.5) |
CI, confidence ratio; OR, odds ratio; PR, progesterone receptor; SNP, single nucleotide polymorphism; SPTB, spontaneous preterm birth.
a
PR SNPs entered as additive term in logistic regression models adjusted for prepregnancy body mass index, race, and treatment group.
Bustos et al. Association of CYP3A and PR SNPs and 17 OHP-C. Am J Obstet Gynecol 2017.