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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: Chem Rev. 2017 Aug 18;118(3):1199–1215. doi: 10.1021/acs.chemrev.7b00145

Figure 14.

Figure 14

Model of inhibitory α-helix-independent ATP binding in a subset of Fic domains. Some Fic domains, such as CdFic, contain additional residues in the Fic domain binding pocket that aid in the coordination of ATP. These additional residues bypass the requirement for the second conserved arginine coordination of the γ-phosphate of ATP.