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(A) VopS AMPylates a conserved threonine of Rho family GTPases. (B) DrrA AMPylates a tyrosine on Rab1b, which prevents association of Rab1b with its GAP. (C) HeLa cells mock transfected. (D) HeLa cells transfected with active VopS. Reproduced from ref 1. Copyright 2010, with permission from Frontiers.
