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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: Chem Rev. 2017 Aug 18;118(3):1199–1215. doi: 10.1021/acs.chemrev.7b00145

Figure 8.

Figure 8

Proposed mechanism of adenylyl transferase (ATase) mediated AMPylation. Three aspartate residues coordinate two Mg2+ ions in the active site. ATP is shown in green; ATase residues are shown in black. Adapted and reproduced from ref 6. Copyright 2015 American Chemical Society.