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. 2017 Aug 23;4(6):165–170. doi: 10.1177/2049936117725935

Table 1.

Percentage of P. aeruginosa isolates with decreased susceptibility to one or more β-lactam agents (n = 179) exhibiting susceptibility to β-lactam monotherapy, as compared to combination therapy with non-β-lactam agents.a

Monotherapy
Additive ciprofloxacin
Additive levofloxacin
Additive gentamicin
Additive tobramycin
% % p-value % p-value % p-value % p-value
Ceftazidime 75 83 0.069 80 0.312 86 0.011 94 <0.001
Cefepime 55 66 0.040 62 0.198 71 0.002 84 <0.001
Aztreonam 34 63 <0.001 56 <0.001 69 <0.001 85 <0.001
Piperacillin-tazobactam 68 76 0.125 73 0.353 79 0.031 89 <0.001
Meropenem 66 75 0.082 72 0.253 78 0.013 88 <0.001
Imipenem 74 83 0.039 83 0.029 87 0.003 93 0.039
a

Includes P. aeruginosa isolates recovered from blood, bone, lower respiratory tract, pleural fluid, cerebrospinal fluid, or peritoneal fluid cultures. The majority of isolates, 117 (65%), was cultured from respiratory tract specimens; while 32 (18%), 13 (7%), 13 (7%) and 4 (2%) isolates were collected from blood, bone, peritoneal fluid and pleural fluid specimens, respectively.