Table 1. In day 15 after the monoarthritis induction, the rats were divided into the following categories and submitted to the protocol of injections.

Ciprofloxacin intrathecal injections	Abbreviation	Dosage μg /rat at day 15.
Free in normal rats	Cipro (N)	20
Free in monoarthritic rats	Cipro (M)	20
Loaded into SLN in normal rats	Cipro nano (N)	20
Loaded into SLN in monoarthritic rats	Cipro nano (M)	10
Saline in normal rats	Saline (N)	20
Saline in monoarthritic rats	Saline (M)	20
Minocycline intrathecal injections	Abbreviation	Dosage μg /rat at day 15.
Free in normal rats	Mino (N)	20
Free in monoarthritic rats	Mino (M)	20
Loaded into SLN in normal rats	Mino nano (N)	20
Loaded into SLN in monoarthritic rats	Mino nano (M)	10
Saline in normal rats	Saline (N)	20
Saline in monoarthritic rats	Saline (M)	20