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. 2018 Apr 15;29(8):964–974. doi: 10.1091/mbc.E17-11-0694

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© 2018 Climer et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 7: — Model depicting COG-dependent intra-Golgi membrane dynamic. (A) The COG complex coordinates retrograde Golgi recycling in WT cells. (B) On COG4 depletion, the COG complex is destabilized destroying Golgi architecture and dysregulating retrograde trafficking and trafficking components. (C) Permanent attachment of COG4 to the membrane with a transmembrane fusion construct restores COG structure and function but only partially restores Golgi organization. Therefore, the trafficking route of TMEM-COG subunits contributed by integral membrane protein TMEM115 likely alters the trafficking dynamic of the COG complex. Trafficking of COG subunits by this method is not amenable to a well-organized Golgi structure and balance between anterograde and retrograde trafficking.